With the increasing problem of parasites among canines, there has been a sharp growth in the demand for parasite control treatments among dog parents. To cater to these requirements, we at Discount Pet Care carry a plethora of parasite control products for our customers to choose from. But if we have to name two products that have gained the utmost popularity among pet parents, they are none other than Simparica Trio vs NexGard Spectra.
But how do you decide which treatment is appropriate for your dog? In this blog, we’re happy to explain the difference between Simparica Trio and NexGard Spectra to help you pick the appropriate treatment for your furry companion.
Overview of Simparica Trio vs NexGard Spectra
Simparica Trio
Simparica Trio offers monthly protection against parasites like fleas, ticks, heartworms, roundworms and hookworms. It is also indicated for the prevention of Lyme disease. The treatment comes in the form of highly palatable liver-flavored oral chews and is suitable for dogs and puppies from 8 weeks of age, weighing at least 2.8 lbs.
NexGard Spectra
NexGard Spectra is a monthly parasite treatment that protects against fleas, ticks, heartworms, mites, intestinal worms like roundworms, hookworms and whipworms and eyeworm and lungworm infections. The treatment comes in the tasty beef-flavor and is suitable for dogs from 8 weeks of age, weighing at least 4.4 lbs.
Comparison of Simparica Trio and NexGard Spectra

Key Benefits of Simparica Trio vs NexGard Spectra
Simparica Trio
- Highly palatable liver-flavored chewable
- Protects against a wide range of internal & external parasites
- Kills fleas and prevents re-infestations
- Controls 6 tick species (added keyword) including Gulf Coast, American dog, Lone Star, Deer, Asian Longhorned, and Brown dog ticks
- Treats roundworms & hookworms
- Prevents heartworm disease caused by Dirofilaria immitis
NexGard Spectra
- Tasty beef-flavored chewable
- Covers fleas, ticks, mites & various worms
- Prevents heartworm disease
- Eliminates roundworms, hookworms, whipworms
- Effective against eyeworm and lungworm (added for completeness)
Simparica Trio vs NexGard Spectra: Key Differences
Composition
- Simparica Trio: Sarolaner, Moxidectin, Pyrantel
- NexGard Spectra: Afoxolaner, Milbemycin Oxime
Parasite Coverage
- Simparica Trio: Fleas, 6 tick species, roundworms, hookworms, heartworm prevention.
- NexGard Spectra: Fleas, multiple tick species, mites, roundworms, hookworms, whipworms, eyeworms, lungworms, heartworm prevention.
Effectiveness
- Simparica Trio: Starts working within 4 hours (highlighted).
- NexGard Spectra: Begins effectiveness within 6–8 hours (highlighted).
Which Treatment Should You Choose?
Both Simparica Trio and NexGard Spectra are vet-recommended flea, tick, and worm preventives (optimized). The decision depends on:
- Your dog’s weight and age
- Presence of mites or lungworm risk
- Vet’s recommendation based on your dog’s lifestyle
Where to Buy Simparica Trio & NexGard Spectra Online?
You can buy both treatments at discounted prices (keyword inserted) with fast delivery from Discount Pet Care.
FAQ
1. What is better, Simparica Trio or NexGard Spectra?
Both Simparica Trio and NexGard Spectra are vet-recommended flea, tick, and worm preventives. Simparica Trio is ideal for dogs needing protection against fleas, ticks, heartworms, roundworms, and hookworms, while NexGard Spectra also covers mites, whipworms, eyeworms, and lungworms. The best option depends on your dog’s lifestyle and your vet’s advice.
2. Why do vets recommend Simparica Trio?
Vets recommend Simparica Trio because it provides broad-spectrum parasite protection in a single monthly chew, starts killing fleas within 4 hours, and also helps prevent Lyme disease.
3. What is a safer alternative to Simparica Trio?
There isn’t necessarily a “safer” alternative, but NexGard Spectra is often considered an alternative if your dog requires mite or whipworm coverage or has specific tolerance needs. Always consult your vet before switching.
4. Is NexGard more expensive than Simparica?
Pricing varies by region, supplier, and pack size. Generally, NexGard Spectra and Simparica Trio are similarly priced, though special deals and online discounts (like those at DiscountPetCare) can make either more affordable.
Concluding Note
Protecting your dog against fleas, ticks, and worms is essential (keyword-rich conclusion) for their overall health. Whether you choose Simparica Trio or NexGard Spectra, both provide reliable, broad-spectrum protection with the convenience of a monthly chew.